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Con este trabajo extenuante, el sudor le molesta a uno.

Con este trabajo extenuante, el sudor le molesta a uno.
With this grueling work, the sweat bothers one.
From Lesson 392:Impersonal statements (uno)·Spanish (Latin America)

Questions & Answers about Con este trabajo extenuante, el sudor le molesta a uno.

Why do we use a uno here instead of just uno?
Because uno is the indirect object of the sentence, not the subject. The verb molestar works like gustar: el sudor (the sweat) is the subject doing the bothering to "one". When uno is the object receiving the action, it requires the preposition a, becoming a uno.
Why is there a le before molesta if we already specify a uno?
In Spanish, when an indirect object is explicitly stated using a (like a uno), you generally must include the matching indirect object pronoun before the verb. Since uno is grammatically third-person singular, we need the pronoun le.
If a woman is speaking, would she say a una instead of a uno?
Yes! While uno is often used as a generic default by people of any gender, female speakers will frequently use una (as in le molesta a una) to make a generic statement that still connects to their own perspective.
Why is the verb molesta singular if "grueling work" implies a lot of intense effort?
The verb molesta is singular because its grammatical subject is el sudor (the sweat), not the work. The phrase Con este trabajo extenuante just sets the background scene. Since el sudor is a singular noun doing the bothering, the verb must be the singular molesta.

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