Più conosco il palazzo, meno mi preoccupa questo trasloco.

It is the Italian equivalent of the English pattern the more ..., the less ....

So:

• Più conosco il palazzo = The more I know the building
• meno mi preoccupa questo trasloco = the less this move worries me

This is a very common structure in Italian:

• Più studi, meglio capisci. = The more you study, the better you understand.
• Più aspetto, meno ho pazienza. = The more I wait, the less patience I have.

Italian uses più and meno directly, without needing a separate word for the the way English does.

No. In this structure, Italian normally does not use che.

You simply say:

• Più conosco il palazzo, meno mi preoccupa questo trasloco.

Not:

• Più che conosco...
• Meno che mi preoccupa...

This is just a fixed comparative pattern in Italian.

Because conoscere and sapere are different verbs in Italian.

• conoscere = to know someone/something, to be familiar with
• sapere = to know a fact, to know how to do something

Here, the speaker means becoming more familiar with the building, so conoscere is the right verb:

• Conosco il palazzo = I know / am familiar with the building

If you used sapere, it would sound wrong in this context.

Compare:

• Conosco Roma. = I know Rome.
• So dov’è Roma. = I know where Rome is.

Palazzo often means a large building, apartment building, or block of flats. Depending on context, it can also mean palace, but here it almost certainly means the building where the move is happening or the building the speaker is getting to know.

So in this sentence, il palazzo is best understood as the building rather than the palace.

Because the verb is being used transitively: something worries someone.

So:

• questo trasloco mi preoccupa = this move worries me

Here:

• questo trasloco is the subject
• mi means me
• preoccupa is worries

By contrast:

• mi preoccupo = I worry or I am worrying

So the difference is:

• Mi preoccupa questo trasloco. = This move worries me.
• Mi preoccupo per questo trasloco. = I worry about this move.

Both are possible Italian, but they mean slightly different things grammatically.

Because its subject is singular: questo trasloco.

Even though mi appears before the verb, mi is only the indirect/object pronoun meaning me. It is not the subject.

So the structure is:

• questo trasloco = singular subject
• preoccupa = singular verb

If the subject were plural, the verb would also be plural:

• Questi traslochi mi preoccupano. = These moves worry me.

Italian often allows the subject to come after the verb, especially when the speaker wants to emphasize the effect on the person first:

• meno mi preoccupa questo trasloco

This is perfectly natural.

The more neutral order would be:

• meno questo trasloco mi preoccupa

That is also correct, but the original version sounds smoother and more idiomatic in many contexts.

Italian word order is more flexible than English, especially when pronouns like mi are involved.

Yes, it is grammatically possible:

• Più conosco il palazzo, meno questo trasloco mi preoccupa.

This version puts more emphasis on questo trasloco as the subject.

The original:

• Più conosco il palazzo, meno mi preoccupa questo trasloco

sounds very natural and idiomatic. In everyday Italian, both are possible, but the original word order is often preferred.

Because this sentence expresses a general relationship that is happening now or in general:

• The more I get to know the building, the less the move worries me.

Italian often uses the present tense for this kind of idea, just as English does.

It does not necessarily mean only right now at this exact moment. It can describe an ongoing process or general truth.

Trasloco usually means a move, especially a house move or the process of moving belongings from one place to another.

It can refer to:

• the act of moving
• the whole relocation process
• sometimes the moving job itself

So questo trasloco means this move.

In traditional learner terms, it is usually easiest to think of mi here as me in it worries me.

Italian grammars may analyze verbs like preoccupare in slightly different ways depending on the explanation style, but for a learner the key point is:

• mi preoccupa = worries me
• ti preoccupa = worries you
• ci preoccupa = worries us

So you should mainly remember the pattern:

• qualcosa mi preoccupa = something worries me

Yes. That would also be correct, but it changes the structure slightly.

• meno mi preoccupa questo trasloco = the less this move worries me
• meno sono preoccupato per questo trasloco = the less worried I am about this move

The meaning is very close, but the original uses the verb preoccupare actively, while the alternative uses the adjective preoccupato.

Both are natural Italian.

Yes, Italian can use a fuller, slightly more formal version:

• Quanto più conosco il palazzo, tanto meno mi preoccupa questo trasloco.

This means the same thing as the original.

However, in everyday usage, the shorter pattern with just più ..., meno ... is very common and natural:

• Più conosco il palazzo, meno mi preoccupa questo trasloco.

Yes, the comma is standard and helpful here because it separates the two linked comparative parts:

• Più conosco il palazzo, meno mi preoccupa questo trasloco.

It works much like in English:

• The more I know the building, the less this move worries me.

You may sometimes see punctuation used more loosely in informal writing, but using the comma is the best choice.

It sounds natural. The structure is completely normal Italian, and the wording is idiomatic.

The sentence gives the idea that becoming more familiar with the building makes the speaker less anxious about the move. That is exactly the kind of relationship Italian often expresses with più ..., meno ....