Después de correr con sandalias nuevas, me salió una ampolla y tuve bastante picor en el talón.

In Spanish, después de + infinitive means after doing something.

So:

• después de correr = after running
• después de comer = after eating
• después de estudiar = after studying

This is a very common structure. In English, we often use after + -ing, but in Spanish you normally use después de + infinitive.

Con here simply means wearing / with. Spanish often uses con in places where English might use in, wearing, or with.

So:

• correr con sandalias nuevas = to run wearing new sandals

You could also say usando sandalias nuevas, but it sounds less natural in this everyday context. Con is the usual, idiomatic choice.

Literally, me salió una ampolla is something like:

• a blister came out on me
• or more naturally, I got a blister

Spanish often uses this kind of structure for things that happen to the body:

• Me salió una ampolla = I got a blister
• Me salió un grano = I got a pimple
• Me salieron ronchas = I broke out in welts / hives

The me does not mean I did it. It shows that the event happened to me.

Salir is very commonly used in Spanish for skin problems or things that appear on the body.

• me salió una ampolla = I got a blister
• me salió un sarpullido = I got a rash

You might also hear apareció una ampolla, but that sounds more detached or descriptive. Me salió is more natural in everyday speech.

Using tuve una ampolla is grammatically possible, but it usually sounds less idiomatic here. Spanish strongly prefers me salió una ampolla for this idea.

In Spanish, countable nouns usually need an article or determiner.

So you say:

• una ampolla = a blister
• un dolor = a pain
• una herida = a wound

Saying just me salió ampolla would be incorrect.

Here, ampolla clearly means blister, especially from friction, like from shoes or sandals.

Be aware that in other contexts, ampolla can also mean a small ampoule or vial in medical/pharmaceutical language. But in this sentence, because of correr con sandalias nuevas and en el talón, it definitely means blister.

Both are possible, but they express the idea a little differently.

• tuve bastante picor = I had quite a lot of itching / itchiness
• me picaba mucho = it itched a lot

The version in the sentence uses the noun picor. This is common in Spanish, especially when talking about symptoms:

• tener dolor
• tener picor
• tener fiebre

Using me picaba mucho el talón would also be natural, but it focuses more directly on the sensation as an action/state: my heel was itching a lot.

Both relate to itching, but there are regional differences.

In Spain, picor is very common and natural. In many parts of Latin America, comezón is also very common.

So for Spain Spanish, picor is a very good choice.

Here, bastante means quite a lot of or a fair amount of.

So:

• tuve bastante picor = I had quite a lot of itching

Bastante can mean enough in some contexts, but here it is working as an intensifier.

Compare:

• Tengo bastante dinero = I have quite a lot of money
• Ya es bastante = That’s enough already

Context tells you which meaning is intended.

Spanish often uses the definite article with body parts where English uses a possessive.

So Spanish prefers:

• me duele la cabeza = my head hurts
• me lavé las manos = I washed my hands
• tuve picor en el talón = I had itching in my heel

Because me already tells you whose body is involved, mi is usually unnecessary.

Using en mi talón is not impossible, but it is less natural here unless you want extra emphasis.

Because the sentence is describing the location of the itching.

• en el talón = in/on the heel

If you said picor del talón, that would sound more like itching of the heel as a noun phrase, not the natural way to express the symptom in this sentence.

So:

• Tuve picor en el talón = I had itching in my heel
• Tenía dolor en la espalda = I had pain in my back

This en + body part pattern is very common.

They are in the preterite because the sentence refers to a specific completed event in the past.

• me salió una ampolla = a blister appeared / I got a blister
• tuve bastante picor = I had quite a lot of itching

This sounds like a finished episode after that run.

If you used the imperfect, it would suggest an ongoing background state:

• me salía una ampolla = a blister was appearing / used to appear
• tenía bastante picor = I was having quite a lot of itching / I used to have quite a lot of itching

For a one-time completed experience, the preterite is the normal choice.

Yes, you could, but it is usually less simple and less natural here.

• Después de correr = after running
• Después de haber corrido = after having run

The second version is more explicit about the action being completed before the next event, but in this sentence that is already obvious. So después de correr is the more natural everyday choice.

Yes, you can move things around somewhat, because Spanish word order is fairly flexible.

For example, these are also possible:

• Después de correr con sandalias nuevas, me salió una ampolla y tuve bastante picor en el talón.
• Me salió una ampolla y tuve bastante picor en el talón después de correr con sandalias nuevas.

The original order is very natural because it first gives the context, then the result.

Because Spanish, like English, often leaves that unspecified unless it matters.

• en el talón = in the heel / on the heel

If you needed to be more precise, you could say:

• en el talón derecho = on the right heel
• en el talón izquierdo = on the left heel

But without that detail, en el talón is perfectly normal.

Picor specifically refers to itching or an itchy sensation, not general pain.

For pain, Spanish would normally use words like:

• dolor = pain
• molestia = discomfort
• escozor = stinging/burning irritation

So in this sentence:

• ampolla gives the physical problem
• picor describes the itchy symptom associated with it