Hablo de manera informal con mis amigos en casa.

Spanish often leaves out subject pronouns because the verb ending already shows who is doing the action.
Here, hablo already means I speak, so yo is not necessary.

You could say Yo hablo de manera informal... if you want extra emphasis or contrast, for example:

Yo hablo de manera informal, pero mi jefe habla de manera formal.

Hablo is the first-person singular present indicative form of hablar.

So:

• hablar = to speak
• hablo = I speak / I am speaking

The ending -o is a very common clue that the subject is I in the present tense.

It can mean either one, depending on context.

In this sentence, it most naturally sounds like a general habit or usual way of speaking:

• I speak informally with my friends at home

If you wanted to strongly emphasize that it is happening right now, Spanish often uses estar + gerund:

• Estoy hablando de manera informal con mis amigos en casa.

But the simple present hablo is very common and flexible.

De manera informal means in an informal way or informally.

It explains how the speaker talks. Grammatically, it works like an adverbial phrase modifying hablo.

So the structure is:

• Hablo = I speak
• de manera informal = in an informal way

It is a very understandable and natural way to express manner in Spanish.

Yes. Both are correct.

These are very close in meaning:

• Hablo de manera informal con mis amigos en casa.
• Hablo informalmente con mis amigos en casa.

A few small notes:

• informalmente is a single adverb
• de manera informal is a phrase meaning basically the same thing
• the phrase version can sound a little more explicit or slightly less compact

Both are good Spanish.

Because hablar con alguien means to speak with someone.

So:

• hablo con mis amigos = I speak with my friends

The preposition con is the normal one after hablar when you mean the person you are talking with.

Compare:

• hablar con alguien = speak with someone
• hablar de algo = speak about something

In your sentence, con mis amigos tells us who the speaker is talking with.

Mis amigos is the most normal and neutral way to say my friends.

Spanish usually puts a possessive adjective before the noun:

• mi amigo = my friend
• mis amigos = my friends

Los amigos míos is possible, but it is more emphatic or stylistically marked. It can sound like:

• my friends, specifically mine

So in a normal sentence like this, mis amigos is the natural choice.

Because mis agrees in number, not in gender.

So:

• mi amigo = my friend
• mi amiga = my friend
• mis amigos = my friends
• mis amigas = my friends

For mi/mis, the form changes only for singular vs. plural, not masculine vs. feminine.

En casa is a very common idiomatic expression meaning at home.

So:

• en casa = at home
• en la casa = in the house / in the home building

The version with no article is often used when the idea is home as a place/state, not the physical building itself.

That is why en casa sounds more natural here.

Not always. It usually means at home, and the exact owner depends on context.

Often it refers to the speaker’s home, but not necessarily in a strongly literal ownership sense. It is more about the idea of being at home.

For a more specific location, Spanish can say things like:

• en mi casa = in my house / at my home
• en casa de mis amigos = at my friends’ house
• en casa de mi abuela = at my grandmother’s house

So en casa by itself is more general.

Yes. Spanish word order is more flexible than English word order.

The original sentence is natural and neutral:

• Hablo de manera informal con mis amigos en casa.

But you can move parts around for emphasis:

• En casa hablo de manera informal con mis amigos.
• Con mis amigos hablo de manera informal en casa.

These alternatives are grammatical, but they may shift emphasis:

• starting with En casa highlights the place
• starting with Con mis amigos highlights who you speak with

The original order is a good standard version.

Yes, it is correct and natural.

That said, many speakers might also choose a slightly shorter version such as:

• Hablo informalmente con mis amigos en casa.

Or, depending on the intended meaning, they might say:

• En casa hablo de manera informal con mis amigos.

So your sentence works well. It is clear, grammatical, and natural for Latin American Spanish.