Il supermercato è in fondo alla strada, a destra.

In Italian, nouns are very often used with an article, even when English would sometimes leave it out.

So il supermercato literally means the supermarket:

• il = the (masculine singular)
• supermercato = supermarket

If you said just supermercato, it would usually sound incomplete in a normal sentence like this.

È is the third-person singular of essere (to be), meaning is.

The accent is important because:

• è = is
• e = and

So in this sentence:

• Il supermercato è... = The supermarket is...

Without the accent, it would be a different word.

In fondo alla strada means at the end of the street.

It breaks down like this:

• in fondo = at the end / at the far end
• alla strada = to the street, but together it becomes the natural Italian way to say of the street / down the street

This is a fixed and very common expression for giving directions.

Alla is a combination of:

• a = to / at
• la = the

So:

• a + la = alla

Italian often combines prepositions and definite articles into one word:

• a + il = al
• a + lo = allo
• a + la = alla
• a + i = ai
• a + gli = agli
• a + le = alle

Because strada is feminine singular, it takes la, so you get alla strada.

Italian often uses the definite article where English may not emphasize it as much.

Here, la strada means the street, referring to the specific street being talked about. In direction phrases, this is very normal:

• in fondo alla strada = at the end of the street
• in fondo alla via = at the end of the road/street

In expressions of direction, Italian usually says:

• a destra = on the right / to the right
• a sinistra = on the left / to the left

These are fixed expressions, so you normally do not use the article here.

Examples:

• Gira a destra. = Turn right.
• La banca è a sinistra. = The bank is on the left.

So a destra is simply the standard way to say it.

The comma separates two location details:

• in fondo alla strada = at the end of the street
• a destra = on the right

So the sentence gives directions in two parts:

1. where along the street it is
2. which side it is on

The comma is natural here, though in some contexts Italian punctuation can vary a little. The meaning stays the same.

Yes, sometimes you can hear sulla destra, which means on the right-hand side.

Compare:

• a destra = more general, very common in directions
• sulla destra = a bit more specific, like on your right / on the right side

For this sentence, a destra is perfectly natural and probably the most common choice.

Italian word order is often similar to English, but location expressions commonly come after the verb:

• Il supermercato è in fondo alla strada, a destra.

This follows a very natural Italian pattern:

• subject
  • verb
    • place information

Italian could sometimes rearrange parts for emphasis, but this version is the most straightforward and idiomatic for giving directions.

There is no gli in this sentence, but a few parts may still be tricky for English speakers:

• supermercato: pronounced roughly soo-per-mer-KAH-to
• è: like eh
• fondo: the o sounds are clear, not like English diphthongs
• strada: pronounced roughly STRAH-da
• destra: pronounced roughly DES-tra

A useful tip: Italian vowels are usually pure and crisp, unlike many English vowels.

Yes. You can say:

• Il supermercato è in fondo alla strada.

That means simply:

• The supermarket is at the end of the street.

Then a destra is just extra information telling you it is on the right.