Aufgrund der Studie bleibt abzuwarten, ob die Wirksamkeit hoch ist.

Questions & Answers about Aufgrund der Studie bleibt abzuwarten, ob die Wirksamkeit hoch ist.

Why is there no es in this sentence, even though the lesson is about es bleibt zu constructions?
In the phrase es bleibt abzuwarten, the es is just a placeholder (a "dummy subject") for the real subject, which is the entire ob clause at the end. Because this sentence puts the phrase Aufgrund der Studie in position 1, that placeholder es is no longer needed to kick off the sentence and is completely dropped. If you wanted to start with the dummy subject, it would be: Es bleibt aufgrund der Studie abzuwarten, ob...
Why is zu written in the middle of the word abzuwarten?
The base verb is abwarten (to wait and see), which is a separable verb. Whenever you use a separable verb in a zu + infinitive construction, the zu must be squeezed directly between the separable prefix (ab-) and the core verb (warten), joining them into a single word: abzuwarten.
Why is the article der used before Studie if it's a feminine noun?
The preposition aufgrund (due to / based on) requires the genitive case. For feminine nouns like die Studie, the definite article changes to der in the genitive case.
How would the grammar change if I used a plural noun instead of the ob clause?
If you replace the ob clause with a regular plural noun, that noun becomes the grammatical subject of the sentence, so the verb bleibt must become plural. For example: Aufgrund der Studie bleiben die Ergebnisse abzuwarten (Based on the study, the results remain to be seen).

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