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Questions & Answers about Estoy seguro de eso.
Why do we use de here instead of sobre or acerca de for "about"?
The adjective seguro forms a set phrase with the preposition de when you are talking about being certain of something. Just like some English verbs and adjectives lock onto specific prepositions, Spanish uses estar seguro de for "to be sure of" or "to be sure about". You must use de here regardless of how it translates into English.
Why is the word for "that" eso instead of ese or esa?
The pronoun eso is neuter. We use it when referring to an abstract concept, a situation, or a statement someone just made. If you were talking about being sure of a specific masculine noun, you might point and use ese. But since "that" here refers to a general idea or fact, it takes the neuter form eso.
Could I use soy instead of estoy here?
Does anything in this sentence change if the speaker is a woman?