Questions & Answers about De todas maneras, voy a llamar.
This is a fixed expression, so its literal pieces do not map neatly onto the English meaning.
- de = of / in / by, depending on context
- todas = all
- maneras = ways / manners
But together, de todas maneras means anyway, in any case, or regardless.
It works like an idiomatic phrase, just as English uses expressions whose literal wording is not the main point.
Very common alternatives are:
- de todos modos
- de todas formas
All three often mean basically the same thing.
Because manera is a feminine noun.
So the adjective or determiner must agree with it:
- todas las maneras
- in this expression: de todas maneras
If the noun were masculine, you would use todos instead.