De todas maneras, voy a llamar.

This is a fixed expression, so its literal pieces do not map neatly onto the English meaning.

• de = of / in / by, depending on context
• todas = all
• maneras = ways / manners

But together, de todas maneras means anyway, in any case, or regardless.

It works like an idiomatic phrase, just as English uses expressions whose literal wording is not the main point.

Very common alternatives are:

• de todos modos
• de todas formas

All three often mean basically the same thing.

Because manera is a feminine noun.

• singular: la manera
• plural: las maneras

So the adjective or determiner must agree with it:

• todas las maneras
• in this expression: de todas maneras

If the noun were masculine, you would use todos instead.

Yes, de todas maneras is natural in Spain, but de todas formas and de todos modos are also very common.

Roughly:

• de todas maneras = anyway / in any case
• de todas formas = anyway / all the same
• de todos modos = anyway / regardless

In everyday speech in Spain, many people may use de todas formas or de todos modos a bit more often, but de todas maneras is absolutely normal.

Spanish often omits subject pronouns when they are not needed, because the verb ending already shows the subject.

• voy = I go / I am going
• so voy a llamar already clearly means I’m going to call

Adding yo is possible, but it usually adds emphasis or contrast:

• Yo voy a llamar, pero tú no haces nada.
  I’m going to call, but you’re not doing anything.

In a neutral sentence, just voy a llamar is the most natural choice.

It is the very common structure:

ir + a + infinitive

Here:

• voy = first person singular of ir (to go)
• a
• llamar = to call

So:

• voy a llamar = I’m going to call

This structure is used to talk about a future action, much like English be going to + verb.

More examples:

• Voy a estudiar. = I’m going to study.
• Vamos a salir. = We’re going to go out.
• ¿Vas a venir? = Are you going to come?

Yes. Both are correct, but they can feel slightly different.

• voy a llamar = I’m going to call
• llamaré = I will call

In many everyday situations, voy a llamar sounds a bit more immediate, conversational, or tied to a current decision/plan.

Llamaré can sound a little more straightforward, definite, or formal depending on context.

For this sentence:

• De todas maneras, voy a llamar.
• De todas maneras, llamaré.

Both work. The version with voy a llamar is very natural in speech.

In Spanish, llamar can mean to call in the phone sense without adding anything else, if the context is clear.

So:

• Voy a llamar. = I’m going to call.

If you want to be more explicit, you can add:

• Voy a llamar a Marta. = I’m going to call Marta.
• Voy a llamarlo. = I’m going to call him.
• Voy a llamar por teléfono. = I’m going to call by phone.

Spanish often leaves out information that the listener can already understand from context.

Because with llamar meaning to call someone, Spanish normally uses the personal a before a specific person.

• Voy a llamar a mi madre.
• Voy a llamar a Juan.

That a is not the same a from the future structure voy a llamar. In a sentence like:

• Voy a llamar a Juan

there are actually two different as:

1. voy a llamar = ir + a + infinitive
2. a Juan = personal a before a person

This is very normal in Spanish.

The comma is natural because de todas maneras is being used as a sentence adverb or discourse marker, like anyway in English.

So the comma helps separate that introductory phrase from the main statement:

• De todas maneras, voy a llamar.

In informal writing, people sometimes omit commas more than they should, but with this kind of introductory phrase, the comma is standard and helpful.

Yes. It is flexible.

You can say:

• De todas maneras, voy a llamar.
• Voy a llamar de todas maneras.

Both are correct.

There can be a slight difference in focus:

• De todas maneras, voy a llamar.
  sounds like Anyway, I’m going to call.
• Voy a llamar de todas maneras.
  sounds more like I’m going to call anyway.

The meaning is very close, but the first places more emphasis on the linking idea anyway.

In standard modern Spanish from most of Spain:

• llamar is usually pronounced roughly like ya-MAR or with a stronger consonant sound at the start, depending on the speaker and region.
• Stress is on the last syllable: lla-MAR

A simple learner-friendly approximation is:

• ya-MAR

But pronunciation varies by region. In most of Spain today, ll and y are pronounced the same or very similarly.

No. Llamar has several common meanings.

It can mean:

• to call / phone
• to call someone by a name
• to attract / catch
• to knock / ring in some expressions

Examples:

• Voy a llamar. = I’m going to call.
• Se llama Ana. = Her name is Ana. / She is called Ana.
• Eso llama la atención. = That attracts attention.
• Llama a la puerta. = Knock on the door.

So the exact meaning depends on context. In your sentence, it clearly means to call.

It often suggests decision despite something else.

Typical implied meanings are:

• Even so, I’m going to call.
• Anyway, I’m going to call.
• In any case, I’m going to call.

So the speaker may be reacting to hesitation, disagreement, uncertainty, or a previous plan. For example:

• No sé si contestará, pero de todas maneras, voy a llamar.
  I don’t know if he/she will answer, but I’m going to call anyway.

So the phrase often carries the sense of regardless of that, this is what I’ll do.