Kiedy jestem zmęczona, wszystko zaczyna mi przeszkadzać, nawet spokojny program w telewizji.

Zmęczona is the feminine singular form of zmęczony (tired).

So the speaker is female:

• jestem zmęczona = I am tired said by a woman
• jestem zmęczony = I am tired said by a man

In Polish, past participle-like adjectives such as zmęczony / zmęczona / zmęczone must agree with the gender of the person speaking.

Here kiedy means when, but in a sentence like this it often has the broader sense of whenever or when(ever) in English.

So:

• Kiedy jestem zmęczona... = When I’m tired...
• Depending on context, it can feel like Whenever I’m tired...

Polish often uses kiedy in places where English might choose either when or whenever.

Because Kiedy jestem zmęczona is a subordinate clause.

Polish normally puts a comma before the main clause when a dependent clause comes first:

• Kiedy jestem zmęczona, wszystko zaczyna mi przeszkadzać.

This is very standard in Polish punctuation.

This literally works like:

• wszystko = everything
• zaczyna = starts / begins
• mi przeszkadzać = to bother me / to get in my way / to annoy me

So the whole phrase means: everything starts to bother me

Polish often uses:

• zaczynać + infinitive = to start doing something

Examples:

• Zaczynam rozumieć. = I’m starting to understand.
• Zaczyna padać. = It’s starting to rain.
• Wszystko zaczyna mi przeszkadzać. = Everything starts bothering me.

Both mi and mnie can mean to me / me, but mi is the unstressed, more common form in normal sentences.

So:

• wszystko zaczyna mi przeszkadzać = natural, neutral
• wszystko zaczyna mnie przeszkadzać would actually be wrong here, because przeszkadzać takes the dative, not the accusative
• wszystko zaczyna przeszkadzać mnie is also not the normal way to say it

The correct dative pronouns are:

• mi = unstressed
• mnie = stressed or emphatic

Compare:

• To mi przeszkadza. = That bothers me.
• To mnie przeszkadza is incorrect with this verb
• To przeszkadza mnie? also incorrect

The verb przeszkadzać requires the dative:

• przeszkadzać komu? czemu? = to bother whom? to what?
• mi, ci, mu, jej, nam, wam, im

Because przeszkadzać is one of those Polish verbs that govern the dative case.

You learn it as:

• przeszkadzać komuś = to bother someone / to interfere with someone

Examples:

• To mi przeszkadza. = That bothers me.
• Hałas przeszkadza dzieciom. = The noise bothers the children.
• Czy to panu przeszkadza? = Does that bother you?

This is different from English, where we simply say bother someone without a special case ending.

This is about aspect.

• przeszkadzać = imperfective
• przeszkodzić = perfective

In this sentence, the idea is general and ongoing: when I’m tired, things start bothering me

That calls for the imperfective verb przeszkadzać, because it describes a process or repeated/ongoing effect.

Compare:

• To zaczyna mi przeszkadzać. = This is starting to bother me.
• To mi przeszkadza. = This bothers me.
• To mi przeszkodziło. = This hindered/stopped me once; it got in the way.

Also, zaczynać normally combines very naturally with an imperfective infinitive:

• zaczyna czytać
• zaczyna pracować
• zaczyna padać
• zaczyna przeszkadzać

In Polish, wszystko is grammatically singular neuter, even though in meaning it refers to many things.

That is why the verb is singular:

• wszystko zaczyna... not wszystkie zaczynają...

Compare:

• Wszystko jest dobrze. = Everything is fine.
• Wszystko mnie denerwuje. = Everything annoys me.

If you were talking about specific plural items, you might use:

• wszystkie rzeczy = all the things
• wszystkie filmy = all the films

But wszystko by itself behaves like a singular word.

Because program is a masculine singular noun, and the adjective must agree with it.

So:

• spokojny program = masculine singular
• spokojna audycja = feminine singular
• spokojne show = neuter singular

Agreement pattern:

• spokojny = masculine
• spokojna = feminine
• spokojne = neuter

Here program means something like TV programme/show.

Yes, basically. Spokojny means calm, peaceful, quiet, or gentle, depending on context.

In spokojny program w telewizji, it suggests a show that is not loud, aggressive, chaotic, or stimulating. A natural English translation could be:

• even a calm TV programme
• even a quiet show on TV
• even a gentle programme on television

So the point is that when the speaker is tired, even something normally harmless and calm becomes irritating.

Because Polish normally says:

• w telewizji = on TV / on television

This is just the standard idiom.

Examples:

• Co jest dziś w telewizji? = What’s on TV today?
• Widziałam to w telewizji. = I saw it on TV.

Even though English uses on TV, Polish uses w telewizji.

Yes. Polish word order is fairly flexible, though each version may sound slightly different in emphasis.

The original:

• Kiedy jestem zmęczona, wszystko zaczyna mi przeszkadzać, nawet spokojny program w telewizji.

Other possible versions:

• Wszystko zaczyna mi przeszkadzać, kiedy jestem zmęczona, nawet spokojny program w telewizji.
• Nawet spokojny program w telewizji zaczyna mi przeszkadzać, kiedy jestem zmęczona.

The original sounds very natural because it first gives the condition: when I’m tired... and then gives the result: everything starts to bother me...

Nawet means even.

It highlights something surprising:

• nawet spokojny program w telewizji = even a calm TV programme

The idea is: if even that bothers me, then my tiredness is really affecting me.

Polish often uses nawet exactly like English even:

• Nawet on to wie. = Even he knows that.
• Nie mam nawet chwili. = I don’t have even a moment.
• Nawet kawa mi nie pomaga. = Even coffee doesn’t help me.

They are close, but not always identical in feel.

• program w telewizji = a programme on TV
• program telewizyjny = a television programme / TV programme

The first emphasizes where it is seen: on television. The second is a more compact adjective-noun phrase.

In this sentence, spokojny program w telewizji sounds natural and conversational. A speaker is just referring to something playing on TV.

It can cover both ideas, depending on context.

Core meanings of przeszkadzać include:

• to bother
• to disturb
• to get in the way
• to interfere

In this sentence, the sense is emotional/psychological:

• everything starts to bother me / irritate me

In other contexts it can be more literal:

• Hałas mi przeszkadza. = The noise bothers me.
• Ten stół przeszkadza w przejściu. = This table gets in the way of walking through.

So here bother is the best interpretation.