kanozyo ha atarasii syokuba ni nareruno ni zikan ga kakaru.

Here, のに is not the “even though/although” conjunction. It’s の (nominalizer) + に meaning “for (doing)” in the fixed pattern V-plain + のに + N(時間/お金/手間) + がかかる = “it takes N to do V.” Structure: [新しい職場に慣れる] のに [時間がかかる] → “It takes time to get used to a new workplace.” The “although” のに links two clauses (e.g., 雨なのに出かける). In this sentence, の nominalizes the verb phrase, and that noun-like chunk is then marked by に.

• V-のに時間がかかる focuses on the resources required to perform V: “It takes time (money, effort) to V.”
• V-まで時間がかかる focuses on the duration until the state/event V happens: “It takes time until one gets used to it.” Both are often interchangeable in meaning, but:
• のに highlights the “cost” of the process.
• まで highlights the endpoint and the time leading up to it.

は sets 彼女 as the topic (what we’re talking about). It’s natural if she is already known in context: “As for her, it takes time…” If you use が with 彼女, you’re marking her as the subject of the subordinate clause 彼女が慣れる, often to introduce her as new information or to contrast with others.

• お金がかかる (costs money)
• 手間がかかる (takes labor/effort)
• 費用がかかる / コストがかかる (incurs cost)
• 期間がかかる / 時間がかかる (takes time) Same pattern: V-のにNがかかる (It takes N to do V).

• 慣れる: to become used/accustomed to something (broad, neutral). Pattern: Xに慣れる.
• 馴染む: to blend/fit in, to feel at home (more about harmony/affinity). Pattern: Xに馴染む. Both can work with 職場, but 慣れる is the standard choice for “get used to a workplace,” while 馴染む can imply “fit in well with the culture/people.”