La voce è familiare.

Because voce is a feminine singular noun in Italian, so it takes the feminine singular article la.

• la voce = the voice
• plural: le voci = the voices

In Italian, noun gender is grammatical, so you have to learn voce as feminine.

The accent distinguishes è (is) from e (and).

• è = is
• e = and

So:

• La voce è familiare = The voice is familiar
• La voce e familiare would be a spelling mistake

Familiare is an adjective. It describes voce.

So the structure is:

• La voce = the subject
• è = is
• familiare = familiar

Literally: The voice is familiar.

Because this sentence uses essere (to be), and familiare is a predicate adjective.

Structure:

• La voce
  • è
    • familiare

This is exactly like English:

• The voice is familiar

If you put the adjective directly after the noun, that is also possible in some contexts:

• una voce familiare = a familiar voice

So compare:

• La voce è familiare = The voice is familiar
• Una voce familiare = A familiar voice

Because many Italian adjectives have the same form for masculine singular and feminine singular. Familiare is one of them.

Forms of familiare:

• masculine singular: familiare
• feminine singular: familiare
• masculine plural: familiari
• feminine plural: familiari

So:

• La voce è familiare
• Il suono è familiare
• Le voci sono familiari
• I suoni sono familiari

Usually, yes, in a sentence like this. Familiare often means familiar / recognizable / known to you from before.

So La voce è familiare means:

• The voice is familiar
• or naturally in English, sometimes That voice sounds familiar

Be careful, though: familiare can also relate to family in other contexts, depending on the sentence. But here the meaning is clearly familiar.

A simple pronunciation guide:

• voce ≈ VOH-cheh
• familiare ≈ fah-mee-lee-AH-reh

A few useful notes:

• c before e is pronounced like ch in church
• final vowels are pronounced clearly in Italian
• voce has two syllables: vo-ce
• familiare has five syllables: fa-mi-lia-re

Normally, no. In a basic sentence like this, Italian usually needs the article:

• La voce è familiare.

Leaving it out would sound unnatural in standard Italian.

Italian uses articles more often than English does, so where English might sometimes omit the, Italian often keeps it.

Yes, depending on context, that can be a very natural English translation.

Italian says literally:

• La voce è familiare = The voice is familiar

But natural English often prefers:

• That voice sounds familiar

So the exact English wording may change, even though the Italian structure stays the same.

The plural is:

• Le voci sono familiari. = The voices are familiar.

Changes:

• la → le
• voce → voci
• è → sono
• familiare → familiari

This is a good example of how both nouns and adjectives change in the plural.