אני לא רוצה לדבר איתו עכשיו, כי אני עייפה מאוד.

Hebrew often repeats the subject pronoun when a new clause begins, even if English might leave it out.

So in:

אני לא רוצה לדבר איתו עכשיו, כי אני עייפה מאוד.

you get:

• אני לא רוצה... = I do not want...
• כי אני עייפה מאוד = because I am very tired

In English, because I’m very tired sounds natural, and Hebrew does the same by saying כי אני.... You usually do not omit אני here.

In Hebrew, after a verb like רוצה (want), the next verb usually appears in the infinitive form, which already includes the idea of to.

• רוצה לדבר = want to speak / want to talk

The infinitive here is לדבר, and the prefix ל־ is the normal marker of the infinitive in Hebrew.

So:

• לדבר = to speak / to talk

לא means not and is the standard way to negate a sentence in Hebrew.

• אני רוצה = I want
• אני לא רוצה = I do not want

It comes before the verb it negates.

The verb לדבר (to speak / to talk) does not take a direct object the way English sometimes seems to. To say talk to someone in Hebrew, you usually use עם or את in its special prepositional form.

Here:

• איתו = with him / to him in this context

So:

• לדבר איתו = to talk to him

Literally, איתו comes from את + הוא, but in modern Hebrew with verbs like לדבר, it often corresponds to English to him or with him, depending on context.

איתו means with him, and in many contexts it is also used where English says to him after talk/speak.

Breakdown:

• base form: את
• with he / him: איתו

Other similar forms are:

• איתי = with me
• איתך = with you (masculine singular)
• איתך = with you (feminine singular; same spelling in everyday writing)
• איתה = with her
• איתנו = with us

So לדבר איתו is the normal Hebrew way to say talk to him.

Because the speaker is feminine.

Hebrew adjectives must agree with the gender and number of the person or thing they describe.

• אני עייף = I am tired (male speaker)
• אני עייפה = I am tired (female speaker)

So this sentence is being said by a woman or girl.

Only the gendered adjective would change:

• אני לא רוצה לדבר איתו עכשיו, כי אני עייף מאוד.

Everything stays the same except:

• עייפה → עייף

because a male speaker says עייף.

In the present tense, Hebrew usually does not use a separate word for am / is / are.

So:

• אני עייפה literally looks like I tired
• but it means I am tired

This is completely normal in Hebrew present-tense sentences.

Compare:

• הוא עייף = He is tired
• הם עייפים = They are tired

No present-tense form of to be is needed.

מאוד means very.

In Hebrew, it often comes after the adjective:

• עייפה מאוד = very tired

This is different from English, where very comes before the adjective.

More examples:

• טוב מאוד = very good
• גדול מאוד = very big
• חשוב מאוד = very important

Hebrew word order is somewhat flexible, but this order is very natural:

• לדבר איתו עכשיו = to talk to him now

The adverb עכשיו (now) often comes after the verb phrase or after the object/prepositional phrase.

You could hear slightly different word orders depending on emphasis, but the given one is standard and natural.

Yes. כי is the common word for because in everyday Hebrew.

So:

• כי אני עייפה מאוד = because I am very tired

It can also mean that in some other contexts, so learners need to rely on context.

For example:

• אני יודע כי... can sound literary for I know that...
• but in everyday speech, כי very often means because

Here the meaning is clearly because.

It can mean both, depending on context.

• לדבר עברית = to speak Hebrew
• לדבר איתו = to talk to him

So in this sentence, לדבר איתו is best understood as to talk to him, though speak with him would also fit.

A natural pronunciation is:

Ani lo rotzah ledaber ito akhshav, ki ani ayefah me'od.

A rough guide:

• אני = ah-NEE
• לא = loh
• רוצה = roh-TSAH (female form in pronunciation here matches the spelling)
• לדבר = leh-dah-BER
• איתו = ee-TOH
• עכשיו = akh-SHAV
• כי = kee
• עייפה = ah-yeh-FAH
• מאוד = meh-OD

Different accents may vary a little, especially with עכשיו and עייפה.

Yes, but it sounds more formal or literary.

• איתו = common, everyday spoken Hebrew
• עמו = more formal/literary with him

So in normal conversation, איתו is the better choice.

It is neutral everyday Hebrew and sounds completely natural in conversation.

Nothing in it is especially slangy or especially formal. It is the kind of sentence a person would naturally say in daily life.

Yes. If you remove עכשיו, the sentence becomes:

אני לא רוצה לדבר איתו, כי אני עייפה מאוד.

That means:

I don’t want to talk to him, because I’m very tired.

Adding עכשיו makes it more specific: right now / now. It suggests the speaker may not want to talk at this moment, even if that could change later.