Δεν μπορώ να λύσω τον κόμπο με το ένα χέρι, οπότε σε περιμένω να με βοηθήσεις.

Δεν is the normal negation for statements and facts:

• Δεν μπορώ = I can’t
• Δεν ξέρω = I don’t know

Μην is used mainly with:

• negative commands: Μην πας = Don’t go
• some να-clauses: Θέλω να μην αργήσεις = I want you not to be late

So here, the speaker is simply stating a fact: Δεν μπορώ.

In Greek, μπορώ is normally followed by a να-clause:

• Μπορώ να έρθω = I can come
• Μπορώ να το κάνω = I can do it

So:

• Δεν μπορώ να λύσω... = I can’t untie/solve...

This is one of the most common Greek patterns. English uses can + verb, but Greek uses μπορώ + να + verb.

Λύσω here is the aorist subjunctive form, used after να.

Greek often chooses between:

• present subjunctive for an ongoing/repeated action
• aorist subjunctive for a single complete action

Here, untying the knot is seen as one complete action, so Greek uses:

• να λύσω = to untie it / to solve it as a whole action

Compare:

• Δεν μπορώ να λύνω κόμπους με ένα χέρι.
  = I can’t be untying knots with one hand / I’m not able to do that in general
• Δεν μπορώ να λύσω τον κόμπο...
  = I can’t untie the knot... (this specific act)

Yes, λύνω can mean several related things, depending on the object:

• λύνω ένα πρόβλημα = solve a problem
• λύνω έναν κόμπο = untie a knot
• λύνω τα κορδόνια = untie the shoelaces

So in this sentence, because the object is τον κόμπο (the knot), the meaning is clearly untie.

Τον κόμπο is the accusative singular form, because it is the direct object of λύσω.

The noun is:

• nominative: ο κόμπος = the knot
• accusative: τον κόμπο = the knot (as object)

This is a very common masculine pattern:

• ο φίλος → τον φίλο
• ο δρόμος → τον δρόμο
• ο κόμπος → τον κόμπο

So:

• λύνω τον κόμπο = I untie the knot

Because masculine nouns like κόμπος usually change in the accusative singular:

• ο κόμπος → τον κόμπο

The final -ς often drops in the accusative singular for many masculine nouns.

That is why you see:

• subject: Ο κόμπος είναι σφιχτός. = The knot is tight.
• object: Λύνω τον κόμπο. = I untie the knot.

Here με means with, expressing the means or instrument:

• με το χέρι = with the hand
• με το ένα χέρι = with one hand

So the phrase means that the speaker is trying to do it using only one hand.

The structure is:

• με
  • accusative noun phrase

Examples:

• γράφω με μολύβι = I write with a pencil
• ανοίγω την πόρτα με το κλειδί = I open the door with the key

Greek often uses the article in places where English might not.

• με το ένα χέρι literally = with the one hand
• natural English = with one hand

This combination article + number is very common in Greek:

• το ένα παιδί = the one child
• τη μία φορά = the one time / one time
• με το ένα χέρι = with one hand

It can sound slightly more concrete or specific than bare ένα χέρι, but in many contexts it is simply the natural Greek way to say it.

Οπότε here means so, therefore, or as a result.

It links the first idea to the consequence:

• Δεν μπορώ να λύσω τον κόμπο με το ένα χέρι, οπότε...
• I can’t untie the knot with one hand, so...

Other Greek connectors you might also see are:

• άρα = therefore / so
• λοιπόν = so / well then
• γι’ αυτό = for that reason / that’s why

But οπότε is very natural in everyday speech.

Because σε here is a weak object pronoun (you) and weak object pronouns usually come before the verb in Greek:

• σε βλέπω = I see you
• σε θέλω = I want you
• σε περιμένω = I’m waiting for you

So Greek says:

• σε περιμένω

not normally:

• περιμένω σε

The second version may appear only in special emphatic or nonstandard contexts, but the normal pattern is pronoun before the verb.

Yes. In Greek, περιμένω can take a direct object and mean wait for someone or something:

• Περιμένω το λεωφορείο. = I’m waiting for the bus.
• Σε περιμένω. = I’m waiting for you.

English needs wait for, but Greek often uses just the verb plus its object.

So:

• σε περιμένω literally = I wait you
• natural English = I’m waiting for you

This is a very common Greek pattern:

• περιμένω κάποιον να κάνει κάτι
• I wait for someone to do something

So:

• σε περιμένω να με βοηθήσεις = I’m waiting for you to help me

Grammatically:

• σε = you (the person being waited for)
• περιμένω = I wait
• να με βοηθήσεις = to help me

Greek often uses a να-clause where English uses an infinitive structure like for you to help me.

First, με already appears before the verb:

• να με βοηθήσεις = to help me

The pronoun με (me) comes before the verb, just like σε did earlier.

Second, βοηθήσεις is the aorist subjunctive after να, because helping is viewed as one complete action:

• να με βοηθήσεις = to help me / for you to help me

If you used a present form like να με βοηθάς, it would suggest ongoing or repeated help:

• να με βοηθάς = to be helping me / to help me regularly

But here the meaning is a single act of help, so βοηθήσεις is the natural choice.

Because με is the weak object pronoun meaning me, and these pronouns usually come before the finite verb in Greek:

• με βλέπει = he sees me
• με ξέρεις = you know me
• να με βοηθήσεις = to help me

So Greek word order is:

• να με βοηθήσεις

not normally:

• να βοηθήσεις με

They refer to two different people:

• σε περιμένω = I’m waiting for you
• να με βοηθήσεις = for you to help me

So:

• σε = you
• με = me

Putting it together:

• σε περιμένω να με βοηθήσεις = I’m waiting for you to help me

This kind of double-pronoun sentence is very normal in Greek.

Some parts could move, but not everything equally freely.

The most fixed parts are the weak pronouns:

• σε περιμένω
• να me βοηθήσεις

Those pronouns normally stay before the verb.

But other elements can move for emphasis. For example:

• Δεν μπορώ να λύσω τον κόμπο με το ένα χέρι...
• Με το ένα χέρι δεν μπορώ να λύσω τον κόμπο...

Both are possible, but they emphasize slightly different things.

So Greek word order is flexible, but clitic pronouns like σε and με strongly prefer their normal position before the verb.

Yes, it is natural.

A Greek speaker might also say similar versions such as:

• Δεν μπορώ να λύσω τον κόμπο με το ένα χέρι, γι’ αυτό σε περιμένω να με βοηθήσεις.
• Δεν μπορώ να λύσω τον κόμπο μόνο με το ένα χέρι, οπότε περίμενα να με βοηθήσεις.
  (depending on context)

But the original sentence is perfectly normal and understandable. It uses very common spoken Greek structures:

• δεν μπορώ να...
• οπότε
• σε περιμένω να...
• να με βοηθήσεις

It breaks down like this:

• Δεν μπορώ = I can’t
• να λύσω = to untie
• τον κόμπο = the knot
• με το ένα χέρι = with one hand
• οπότε = so
• σε περιμένω = I’m waiting for you
• να με βοηθήσεις = to help me

So the full pattern is:

1. a negative statement of inability
2. the reason/problem
3. a connector showing consequence
4. waiting for another person
5. a να-clause expressing what that person is expected to do

It is a very useful model for building your own Greek sentences.