Mám zkušenosti s touto prací.

In Czech, zkušenost is a countable noun: one experience = jedna zkušenost, several experiences = zkušenosti.

Very often, Czech uses the plural zkušenosti where English would simply say experience in a general sense.

So:

• Mám zkušenosti s touto prací. = I have experience with this work/job.
• literally, it feels more like I have experiences with this work, but that is just how Czech normally expresses it.

This is a very common pattern:

• mít zkušenosti s něčím = to have experience with something

Mám is the 1st person singular present tense of mít = to have.

So:

• mám = I have

Some other forms of mít:

• mám = I have
• máš = you have
• má = he/she/it has
• máme = we have
• máte = you have
• mají = they have

So the sentence starts very straightforwardly:

• Mám... = I have...

The preposition s here means with.

In this sentence, Czech uses the pattern:

• mít zkušenosti s + instrumental case

So:

• s touto prací = with this work/job

This is the normal construction after zkušenosti when you say what kind of experience you have.

Examples:

• Mám zkušenosti s dětmi. = I have experience with children.
• Mám zkušenosti s počítači. = I have experience with computers.
• Mám zkušenosti s touto prací. = I have experience with this work/job.

Because s requires the instrumental case, and tato changes in the instrumental.

The basic feminine form is:

• tato = this

But after s, you need the instrumental feminine singular:

• touto

So:

• tato práce = this work/job
• s touto prací = with this work/job

This is part of the declension of ten / ta / to:

• masculine: tím
• feminine: touto
• neuter: tím

For the same reason: the preposition s takes the instrumental case.

The dictionary form is:

• práce = work, job

But in the instrumental singular, it becomes:

• prací

So:

• práce = work/job
• s prací = with work / with the job

And with the demonstrative:

• s touto prací = with this work/job

So both words after s are changing because of case:

• tato práce
  becomes
• s touto prací

It is the instrumental case.

More precisely:

• touto = instrumental singular, feminine
• prací = instrumental singular, feminine

Why feminine? Because práce is a feminine noun.

So the structure is:

• s
  • instrumental
• s touto prací

This is a very useful pattern to remember, because s often uses the instrumental when it means with.

Práce can mean several related things depending on context:

• work
• job
• piece of work
• sometimes even task

In this sentence, the exact English translation depends on context.

Possible meanings:

• I have experience with this kind of work.
• I have experience with this job.
• I have experience doing this work.

If this is from a professional context, it often suggests experience with a type of work or role. If the context is more concrete, it could mean experience with a particular task or assignment.

So práce is a flexible word, just like work can be in English.

Yes, you can, but it means something a little different.

• Mám zkušenosti s touto prací. = I have experience with this work/job.
  This is the more usual way to talk about general experience.

• Mám zkušenost s touto prací. = I have an experience with this work/job / I have one instance of experience with this work.
  This sounds more limited or more specific.

In most situations, if you mean general background or professional experience, zkušenosti in the plural is more natural.

So for learners, a good default is:

• mít zkušenosti s... = to have experience with...

The neutral word order here is:

• Mám zkušenosti s touto prací.

That is the most natural choice in many contexts.

But Czech word order is more flexible than English, and you can move things around for emphasis. For example:

• S touto prací mám zkušenosti.
  This emphasizes with this work.

• Zkušenosti s touto prací mám.
  This can sound contrastive, like I do have experience with this work.

Even though these are possible, the original sentence is the safest and most neutral form for a learner.

Both s and se are forms of the same preposition.

Usually:

• s is used before many words
• se is used when pronunciation is easier that way, especially before difficult consonant clusters

Here, s touto prací is easy to pronounce, so s is normal.

Examples:

• s bratrem = with my brother
• se sestrou = with my sister

So in your sentence:

• s touto prací is correct and natural

A rough pronunciation guide:

• touto ≈ TOH-oo-toh
• prací ≈ PRA-tsee

A few useful notes:

• ou in Czech is a real diphthong, somewhat like the oa/u glide in English go or though, but not exactly the same.
• c in Czech is pronounced like ts.
• í is a long ee sound.

So:

• Mám zkušenosti s touto prací.
  roughly: maam zkoo-sheh-nos-tee s TOH-oo-toh PRA-tsee

That is only an approximation, but it can help at first.

Yes, it is grammatical and natural. It clearly means that the speaker has experience connected with this kind of work or this specific work.

That said, depending on context, Czech might also use other phrases:

• Mám s touto prací zkušenosti. = same meaning, slightly different emphasis
• Mám zkušenosti v této oblasti. = I have experience in this field
• Mám zkušenosti s touto pozicí. = I have experience with this position/role
• Pracoval(a) jsem v tomto oboru. = I have worked in this field

So your sentence is good, but in real life Czech speakers may choose a slightly different expression depending on whether they mean:

• a specific task
• a job role
• a field of work
• a profession in general