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Desgraciadamente, esta semana no hemos vendido nada.

Desgraciadamente, esta semana no hemos vendido nada.
Unfortunately, we have not sold anything this week.
From Lesson 552:Sentence adverbs (sinceramente, lógicamente)·Spanish (Spain)

Questions & Answers about Desgraciadamente, esta semana no hemos vendido nada.

Why is Desgraciadamente separated by a comma here?
Desgraciadamente is acting as a sentence adverb. Instead of describing how the action was done, it expresses the speaker's overall attitude toward the entire situation. In Spanish, when these adverbs introduce a sentence, they must be set off by a comma.
Could I put Desgraciadamente at the end of the sentence instead?
Yes, but it changes the emphasis. When placed at the beginning, it immediately sets the speaker's tone. If you put it at the end (Esta semana no hemos vendido nada, desgraciadamente.), it feels more like an afterthought. Notice that it still requires a comma to separate it from the main clause.
Why is the present perfect (hemos vendido) used here instead of the preterite (vendimos)?
In Spain, the present perfect (pretérito perfecto) is the standard tense for actions that occur in a time period that is not yet finished from the speaker's perspective. Because the sentence specifies esta semana (this week), the time frame is still ongoing, making hemos vendido the natural choice.
Why does the sentence use both no and nada?
Spanish requires a double negative when a negative word (like nada, nadie, or nunca) comes after the verb. You must place no before the verb to establish the negative structure (no hemos vendido nada).

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