Learn Spanish (Spain): El hotel grande está en la calle nueva.

In Spanish, the preposition en is very flexible. It can mean 'in', 'on', or 'at' depending on the context. When talking about a location like a street, en la calle covers both 'in the street' and 'on the street'.

Why is the verb está used here instead of es?

We use está (from the verb estar) because we are talking about a physical location. A helpful rule for beginners is that we always use estar to say where something is located, even if a building's location is permanent.

Why is it hotel grande and calle nueva instead of putting the describing words first like in English?

In Spanish, describing words (adjectives) almost always come after the noun they describe. So, 'the big hotel' becomes el hotel grande (the hotel big) and 'the new street' becomes la calle nueva (the street new).

The word calle ends in an 'e'. How do I know it is feminine and uses la and nueva?

Words ending in 'e' don't have a strict rule for being masculine or feminine, so you just have to memorize their gender as you learn them. Calle is a feminine noun, which is why it takes the feminine word for 'the' (la) and the feminine describing word for 'new' (nueva).