Она не могла не приехать в офис вопреки рекомендациям врача.

Questions & Answers about Она не могла не приехать в офис вопреки рекомендациям врача.

Why is рекомендациям in the Dative case here?
The preposition вопреки (contrary to / in spite of) always requires the Dative case. It expresses an action happening in defiance of a condition, obstacle, or advice, turning the plural рекомендации into the Dative plural рекомендациям.
Could I use против (against) instead of вопреки in this sentence?
You could, but it would change the grammar and tone. The preposition против takes the Genitive case (против рекомендаций). However, вопреки is much more natural here because it specifically implies doing something in spite of advice or expectations, whereas против sounds more like active, direct opposition.
How does the double negative не могла не приехать work to mean "could not help but"?
In Russian, combining не мочь (to not be able) with another не and an infinitive creates a strong positive obligation: "cannot fail to" or "cannot help but." The two negatives logically cancel each other out, emphasizing that she felt she absolutely had to come.
Why do we use the perfective verb приехать in this double negative structure instead of the imperfective?
Even though the construction uses не (which sometimes triggers the imperfective aspect), the overall meaning describes a single, successfully completed action that actually happened. Because she made one specific, completed trip to the office, the perfective aspect приехать is required.

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