Breakdown of sohu ha byouki ni yowai.
はha
topic particle
祖父sohu
grandfather
祖父 is a formal alternative for grandfather. You might encounter this word in written contexts or official documents. In most contexts it's advised to use お祖父さん instead, as it sounds more friendly and respectful.
病気byouki
sickness, illness, disease
〜 に 弱い〜 ni yowai
to be sensitive to; to be susceptible to
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