En el supuesto de que siga el acúfeno, les avisaremos.

It means something like in the event that, if it turns out that, or on the assumption that.

It is a fairly formal expression. In everyday speech, many speakers would more often say simply:

• Si sigue el acúfeno... = If the tinnitus continues...

So en el supuesto de que sounds more official, written, legal, or medical.

Because en el supuesto de que triggers the subjunctive.

The sentence is talking about a hypothetical or uncertain situation, not a confirmed fact. In Spanish, that kind of idea often requires the subjunctive.

So:

• siga = present subjunctive of seguir
• sigue = present indicative of seguir

Here, Spanish chooses the subjunctive because the continuation of the tinnitus is being presented as a possibility or condition, not as something definitely happening.

Yes. That would be a very natural alternative.

Compare:

• En el supuesto de que siga el acúfeno, les avisaremos.
• Si sigue el acúfeno, les avisaremos.

Both can mean basically the same thing, but the first is more formal and more distant in tone. The second is more straightforward and conversational.

A learner should recognize that the original sentence is not unusual, but it is more elevated than everyday speech.

Because seguir here means to continue, and el acúfeno is its subject.

So siga el acúfeno literally means:

• the tinnitus continues
• or more literally, the tinnitus should/may continue in this subjunctive structure

Spanish often places the verb before the subject, especially in formal styles or after certain structures. It is still the subject even though it comes after the verb.

You could think of it as:

• que el acúfeno siga

That word order may feel easier to an English speaker, but que siga el acúfeno is perfectly normal Spanish.

Acúfeno is the medical term for tinnitus.

In Spain, acúfeno is a standard medical word. You may also hear related wording depending on context, but acúfeno is correct and fairly technical.

The singular is:

• el acúfeno

The plural is:

• los acúfenos

Spanish often uses the definite article with conditions, symptoms, and abstract or medical nouns where English may not.

So Spanish says:

• el acúfeno

where English might simply say:

• tinnitus

This is very normal Spanish usage. The article does not necessarily mean a specific, one-time tinnitus episode in the way English learners might expect; it is just how Spanish commonly phrases it.

Les is an indirect object pronoun meaning to them or to you (plural/formal), depending on context.

So les avisaremos can mean:

• we will let them know
• we will inform them
• or we will let you know if speaking formally to more than one person

Without more context, it is ambiguous.

A native English speaker may expect Spanish to spell this out more clearly, but Spanish often leaves it to context.

Both are possible.

• avisaremos = simple future, we will inform / we will let know
• vamos a avisar = near future, we’re going to inform / let know

The simple future often sounds slightly more formal or written, which fits the tone of en el supuesto de que.

So the sentence is stylistically consistent: both the condition and the main clause sound formal.

Not necessarily. Avisar is broader than English warn.

It can mean:

• to inform
• to notify
• to let someone know
• sometimes to warn, depending on context

In this sentence, les avisaremos most likely means we will let them/you know or we will inform them/you, not specifically we will warn them/you.

Because the sentence begins with a conditional or introductory clause:

• En el supuesto de que siga el acúfeno, ...

Spanish commonly separates that introductory clause from the main clause with a comma, especially in formal writing.

So the structure is:

• conditional clause
  • comma + main clause

This is similar to English:

• If the tinnitus continues, we will let you/them know.

Yes, but it is usually unnecessary.

You could say:

• En el supuesto de que siga el acúfeno, nosotros les avisaremos.

But Spanish normally omits subject pronouns unless they are needed for emphasis, contrast, or clarity.

Since avisaremos already tells you the subject is we, nosotros is not needed.

Yes, definitely.

The main signs of formality are:

• en el supuesto de que instead of simple si
• the medical term acúfeno
• the use of avisaremos, which fits a formal or professional tone

It sounds like something you might read or hear in a medical, administrative, or legal context rather than casual conversation.

Because the two verbs do different jobs in the sentence.

• siga is inside the hypothetical condition, so it takes the subjunctive
• avisaremos is the main action that will happen if that condition is met, so it stays in the indicative future

This is a very common Spanish pattern:

• subjunctive in the uncertain, hypothetical, or dependent clause
• indicative/future in the main clause

So the sentence structure is completely normal:

• En el supuesto de que + subjunctive, future indicative