השכונה שקטה, למרות שהיא קרובה לעבודה שלי.

In Hebrew, the verb to be is usually not written in the present tense when linking a subject to an adjective or noun.

So:

• השכונה שקטה = the neighborhood is quiet
• literally: the neighborhood quiet

This is completely normal Hebrew.
If the sentence were in the past or future, Hebrew would use forms of היה:

• השכונה הייתה שקטה = the neighborhood was quiet
• השכונה תהיה שקטה = the neighborhood will be quiet

Because שכונה is a feminine singular noun, and adjectives in Hebrew usually agree with the noun in gender and number.

• שכונה = neighborhood, feminine singular
• שקטה = quiet, feminine singular form

Compare:

• רחוב שקט = a quiet street
  (רחוב is masculine)
• שכונה שקטה = a quiet neighborhood
  (שכונה is feminine)

So the adjective changes to match the noun.

Many Hebrew nouns ending in -ה are feminine, and שכונה is one of them.

There is no single rule that works for every noun, but the ending is a strong clue. Since שכונה is feminine, words that describe it also become feminine:

• השכונה גדולה = the neighborhood is big
• השכונה נעימה = the neighborhood is pleasant
• השכונה שקטה = the neighborhood is quiet

The prefix ה־ is the definite article, meaning the.

So:

• שכונה = a neighborhood / neighborhood
• השכונה = the neighborhood

Hebrew attaches the directly to the beginning of the word instead of writing it as a separate word.

למרות means despite, in spite of, or in many sentences like this, although.

In this sentence:

• למרות שהיא קרובה לעבודה שלי = although it is close to my work

A very useful thing to notice is that למרות is often followed by:

• a noun: למרות הגשם = despite the rain
• or by ש־ plus a full clause: למרות שהיא קרובה... = although it is close...

So here, למרות introduces a contrast: the neighborhood is quiet even though it is close to work.

The ש־ here means that and connects the clause to למרות.

So:

• היא קרובה לעבודה שלי = it is close to my work
• למרות שהיא קרובה לעבודה שלי = although it is close to my work

You can think of ש־ as introducing a subordinate clause. It is extremely common in Hebrew.

Examples:

• אני חושב שהוא צודק = I think that he is right
• שמחתי שהיא באה = I was glad that she came

In your sentence, שהיא is basically that it is / although it is as part of the larger structure.

For the same reason as שקטה: it refers back to השכונה, which is feminine singular.

• היא refers to השכונה
• therefore the adjective must also be feminine singular

So:

• היא קרובה = it/she is close
• not היא קרוב

Compare:

• המשרד קרוב = the office is close
• השכונה קרובה = the neighborhood is close

The adjective קרוב / קרובה often takes the preposition ל־, meaning to:

• קרוב לבית = close to the house
• קרובה לעיר = close to the city
• קרובה לעבודה שלי = close to my work

So the ל־ is just the normal preposition used after close in Hebrew.

Also notice the form:

• ל + עבודה becomes לעבודה

That is just the preposition attached directly to the noun.

A noun followed by שלי is already definite in meaning, so you normally do not add ה־ to the noun.

So:

• העבודה שלי = my work
• עבודה שלי can sometimes appear in certain contexts, but in standard neutral Hebrew, העבודה שלי is the usual full form

After prepositions, Hebrew often contracts naturally:

• ל + העבודה שלי → לעבודה שלי

So לעבודה שלי is the normal form for to my work or close to my work.

שלי means my.

In Hebrew, possession is often expressed with של + a pronoun:

• שלי = of me = my
• שלך = your
• שלו = his
• שלה = her

Unlike English, this usually comes after the noun:

• העבודה שלי = my work
• literally: the work of me

This word order is very normal in modern Hebrew.

A common pronunciation guide is:

ha-shkhuna shketa, lamrot she-hi krova la-avoda sheli

A few pronunciation notes:

• השכונה: the שכ cluster can feel hard for English speakers. The כ here is the throaty sound like kh.
• שקטה: often sounds like shke-TA
• למרות: stress is usually on the last syllable: lam-ROT
• קרובה: kro-VA
• שלי: she-LI

A natural rhythm would be:

ha-shkhuna shketa, lamROT shehi kroVA la-avoDA sheLI

Yes. In everyday Hebrew, עבודה can refer to:

• work in general
• one’s job
• one’s workplace, depending on context

So קרובה לעבודה שלי can sound like:

• close to my work
• close to my job
• close to my workplace

If someone wanted to be more specific, they might choose a different noun, but עבודה is very natural here.

It is normal and helpful, because למרות שהיא קרובה לעבודה שלי is a subordinate clause expressing contrast.

So the comma separates:

• main clause: השכונה שקטה
• contrasting clause: למרות שהיא קרובה לעבודה שלי

In modern Hebrew punctuation, this kind of comma is very common and natural.

Yes. Hebrew has several natural ways to express the same idea. For example:

• השכונה שקטה, אף על פי שהיא קרובה לעבודה שלי.
• השכונה שקטה, למרות הקרבה לעבודה שלי.

The original sentence is very natural and conversational.
Using למרות שהיא... is a common and straightforward way to say although it is...