Πώς αντιμετωπίζεις το άγχος όταν έχεις πολλή δουλειά;

In Greek, ; is the normal question mark.

So:

• Greek ; = English ?
• Greek · (a raised dot) is closer to the English semicolon/colon pause

So the sentence is clearly a question.

Because πώς means how, and the accent helps distinguish it from πως, which usually means that or as.

So:

• πώς = how
• πως = that / as

This is one of the common cases where the accent mark helps prevent confusion.

It is using informal singular you.

You can tell from the verb forms:

• αντιμετωπίζεις
• έχεις

Both are second person singular.

If you wanted formal singular or plural you, Greek would normally use the second person plural:

• Πώς αντιμετωπίζετε το άγχος όταν έχετε πολλή δουλειά;

Αντιμετωπίζεις is the present tense, second person singular form of αντιμετωπίζω.

So:

• dictionary form: αντιμετωπίζω
• αντιμετωπίζεις = you deal with / you αντιμετωπίζεις

In this kind of question, the present tense usually has a habitual meaning, like How do you usually deal with... ?

Also, αντιμετωπίζω literally has the sense of face, confront, or deal with.

Greek often uses the definite article more than English does, including with abstract nouns like stress.

So το άγχος is very natural here.

Grammatically, το άγχος is the direct object of αντιμετωπίζεις.
Also, άγχος is a neuter noun, and its nominative and accusative forms are the same, so you see:

• το άγχος

Without the article, the phrase would sound less natural in this sentence.

It can mean either, depending on context.

• In everyday situations, άγχος often means stress
• In some contexts, it can also mean anxiety

In this sentence, because it talks about having a lot of work, the most natural meaning is stress.

Because δουλειά is a feminine singular noun, and πολλή must agree with it.

So:

• πολλή = feminine singular
• πολύ = usually neuter singular or adverb

That means:

• πολλή δουλειά = a lot of work

This is an agreement issue: the adjective matches the noun in gender, number, and case.

Because Greek, like English, often treats work as an uncountable idea.

So πολλή δουλειά means a lot of work in a general sense.

If you said πολλές δουλειές, that would sound more like:

• many jobs
• many tasks
• lots of things to do

So the singular δουλειά is the natural choice for workload.

Because the sentence is talking about a general or repeated situation:

• when(ever) you have a lot of work

Greek commonly uses the present tense after όταν for this kind of habitual meaning.

So όταν έχεις πολλή δουλειά means something like:

• when you have a lot of work
• whenever you have a lot of work

Yes. Greek word order is fairly flexible.

The given order is very natural:

• Πώς αντιμετωπίζεις το άγχος όταν έχεις πολλή δουλειά;

But you could also say:

• Όταν έχεις πολλή δουλειά, πώς αντιμετωπίζεις το άγχος;

That version puts the when-clause first. The meaning is basically the same, though the emphasis shifts slightly.

The letter χ is not like English ch in chair.

It is a rough sound, like:

• German ch in Bach
• Scottish ch in loch

So:

• έχεις sounds roughly like EH-his or EH-khis, depending on how you hear that Greek sound

In άγχος, the γχ combination is pronounced roughly like ngh:

• άγχος ≈ ANG-hos

The stress falls where the accent mark is:

• άγχος
• έχεις
• δουλειά

Δουλειά is in the accusative singular because it is the object of έχεις.

So in:

• έχεις πολλή δουλειά

the structure is basically:

• you have
  • a lot of work

Since δουλειά is feminine singular, the adjective also appears in accusative feminine singular:

• πολλή δουλειά