En el supuesto de que detectemos hipoacusia, les avisaremos.

En el supuesto de que means something like in the event that, assuming that, or in the case that.

It is a fairly formal expression, so it sounds more official or professional than a simple si. In medical, legal, administrative, or written contexts, it fits very naturally.

Compare:

• Si detectamos hipoacusia, les avisaremos. = If we detect hearing loss, we’ll let you know.
• En el supuesto de que detectemos hipoacusia, les avisaremos. = In the event that we detect hearing loss, we’ll let you know.

The second version sounds more formal and more cautious.

Because en el supuesto de que triggers the subjunctive.

Spanish often uses the subjunctive after expressions that introduce something hypothetical, uncertain, assumed, or not yet confirmed. Here, the detection of hearing loss is only a possibility, not a fact, so Spanish uses:

• detectemos = present subjunctive

Not:

• detectamos = present indicative

This is a very common pattern:

• En caso de que venga, te llamo.
• A menos que llueva, saldremos.
• Es posible que tengan razón.

So in your sentence, detectemos is there because the clause is hypothetical.

Detectemos is the first person plural present subjunctive of detectar.

That means we detect in a subjunctive environment.

Quick breakdown:

• infinitive: detectar
• present indicative: detectamos
• present subjunctive: detectemos

This can be confusing because detectamos can also mean we detect or we detected, depending on context, while detectemos is clearly subjunctive.

Yes, absolutely.

• Si detectamos hipoacusia, les avisaremos.

This is more direct and more common in everyday speech. It means basically the same thing.

The difference is mainly register:

• si detectamos = neutral, everyday, straightforward
• en el supuesto de que detectemos = more formal, more institutional, more cautious

So if you are speaking casually, si detectamos is usually the more natural choice.

Hipoacusia is a medical term meaning hearing loss or reduced hearing.

It is not the most everyday word for many learners, because it is more technical. In ordinary conversation, people might also say things like:

• pérdida de audición = hearing loss
• problemas de audición = hearing problems

But in medical contexts, hipoacusia is very normal and precise.

Les is an indirect object pronoun meaning to you (plural/formal), to them, or sometimes to you (formal singular) depending on context.

In this sentence, it most likely means we will notify you or we will let you know, addressing the patient or the patient’s family in a formal setting.

So:

• avisaremos = we will notify / we will let know
• les = to you / to them

Literally, les avisaremos is we will notify you/them.

In Spain, this kind of formal medical wording is very common.

Because os is used for you all in an informal plural sense in Spain, while les is more formal or can refer to them.

Compare:

• Os avisaremos = We’ll let you all know
  
  • informal plural, used with vosotros
• Les avisaremos = We’ll let you know / We’ll notify them
  
  • formal plural, or sometimes singular formal depending on context, or them

In a professional or medical setting, les avisaremos sounds much more appropriate than os avisaremos, unless the speaker is being explicitly informal.

Because the sentence describes what will happen later if that condition is met.

• avisaremos = we will notify / we will let you know

The structure is:

• hypothetical condition first: En el supuesto de que detectemos hipoacusia
• result afterward: les avisaremos

This is very common in Spanish:

• Si llega el paquete, te avisaré.
• Si encontramos algo, se lo diremos.

So the future here works just like English we will let you know.

Yes, sometimes Spanish can use the present with future meaning, especially in speech:

• En el supuesto de que detectemos hipoacusia, les avisamos.

However, in this specific formal sentence, les avisaremos is better and more natural because it sounds more official and clearly future-oriented.

In general:

• les avisaremos = more formal, more explicit about the future
• les avisamos = possible in some contexts, but less polished here

Here, de que is simply part of the fixed expression en el supuesto de que.

You can think of it as:

• el supuesto = the assumption
• de que... = that...

So literally, it is something like under the assumption that...

This is not a case where you can normally remove de. The phrase is built that way:

• en el supuesto de que...
• en caso de que...
• a condición de que...

These are all set patterns followed by the subjunctive.

Yes, the comma is normal here.

The first part is a conditional or introductory clause:

• En el supuesto de que detectemos hipoacusia

Then comes the main clause:

• les avisaremos

Spanish usually separates that kind of fronted subordinate clause with a comma, especially in formal writing. So the punctuation is standard and helpful.

Yes, it can:

• Les avisaremos en el supuesto de que detectemos hipoacusia.

This is grammatically correct.

However, the original order sounds more natural in formal writing because it presents the condition first and then the consequence. That structure is very common in instructions, notices, and professional communication.

The sentence itself is standard Spanish and would be understood everywhere.

What feels especially natural in Spain is the formal institutional tone:

• en el supuesto de que
• hipoacusia
• les avisaremos

All of that sounds very typical of written medical or administrative Spanish in Spain.

If it were less formal, especially in everyday speech in Spain, you might hear something simpler like:

• Si detectamos algún problema de audición, se lo diremos.
• Si vemos que hay hipoacusia, les avisamos.

So the sentence is not uniquely Peninsular in grammar, but its tone fits very well with formal Spain Spanish.