Esa camisa no es de mi talla.

Because camisa is a feminine singular noun in Spanish, so the demonstrative has to match it in gender and number.

• esa camisa = that shirt
• ese is used with masculine singular nouns, like ese libro

A quick pattern:

• este / esta = this
• ese / esa = that
• aquel / aquella = that over there

So camisa takes esa.

Esa usually means that for a feminine noun. It points to something not right next to the speaker.

In most everyday Latin American Spanish:

• esta camisa = this shirt
• esa camisa = that shirt

You may also hear aquella camisa for something farther away or more distant, but esa is very common in normal conversation.

In Spanish, no normally goes directly before the verb to make the sentence negative.

So:

• Es de mi talla. = It is my size.
• No es de mi talla. = It is not my size.

That is the standard pattern:

• No quiero. = I don’t want to.
• No tengo dinero. = I don’t have money.

Es is the third-person singular form of ser, meaning is.

So:

• esa camisa = that shirt
• es = is
• de mi talla = my size / of my size

Together: That shirt is not my size.

Literally, de mi talla means of my size. Spanish often uses de in expressions where English would simply say my or use a different structure.

So:

• Es de mi talla. = It’s my size.
• Literal sense: It’s of my size.

This is a very natural Spanish way to talk about clothing sizes.

Here, talla means clothing size.

• talla = size for clothes, shoes, etc.
• tamaño = size in a more general sense, like the physical size of an object

Examples:

• ¿Qué talla usas? = What size do you wear?
• El tamaño de la caja = the size of the box

So in this sentence, talla is the correct word because it is about a shirt.

In many contexts, Spanish strongly prefers de mi talla when talking about whether a garment is your size.

So the most natural version is:

• Esa camisa no es de mi talla.

Depending on region and context, you may hear other expressions, but de mi talla is the safest and most standard choice for a learner.

It is natural, but it focuses on size, not directly on fit.

Common possibilities:

• Esa camisa no es de mi talla. = That shirt is not my size.
• Esa camisa no me queda. = That shirt doesn’t fit me.
• Esa camisa me queda grande. = That shirt is too big on me.
• Esa camisa me queda chica/pequeña. = That shirt is too small on me.

In Latin America, no es de mi talla is very good when talking specifically about the labeled size. No me queda is more about how it fits on your body.

Because Spanish often does not need an explicit subject pronoun when the subject is already clear.

In English, you say:

• That shirt is not my size.

In Spanish, the noun itself is already there:

• Esa camisa no es de mi talla.

So there is no need to add a separate word for it.

Yes, but the meaning changes slightly.

• Esa camisa no es de mi talla. = That shirt is not my size.
• La camisa no es de mi talla. = The shirt is not my size.

Use esa when you are pointing out or identifying a specific shirt as that one.

A simple pronunciation guide is:

EH-sah kah-MEE-sah noh ess deh mee TAH-yah

A few notes:

• c before a sounds like k, so camisa starts with ka-
• ll in most of Latin America sounds like y or j/zh depending on region, so talla may sound like TAH-ya or TAH-jah
• Stress:
  • Esa → EH-sa
  • camisa → ka-MEE-sa
  • talla → TA-lla

Yes, if you mean a blouse rather than a shirt.

Then the sentence would be:

• Esa blusa no es de mi talla.

Both camisa and blusa are feminine, so esa still matches.

Here are some very common ones:

• Esta camisa es de mi talla. = This shirt is my size.
• Esa camisa sí es de mi talla. = That shirt is my size.
• Esas camisas no son de mi talla. = Those shirts are not my size.
• Ese pantalón no es de mi talla. = Those pants / that pair of pants is not my size.
• Estos zapatos no son de mi talla. = These shoes are not my size.

Notice how the demonstrative and verb change to match the noun:

• esa camisa / es
• esas camisas / son