Learn French: Ça dépend de mon rendez-vous. - It depends on my appointment.

In French, the verb dépendre (to depend) is almost always followed by the preposition de. Languages often use different prepositions for the same idea, so it is best to memorize the chunk dépendre de as meaning "to depend on".

How do you pronounce dépend? Do you say the "d" at the end?

No, the final "d" in dépend is completely silent. You pronounce it roughly like "day-pon" (with a nasal sound at the end). This is a common rule in French: most final consonants are not pronounced.

Does rendez-vous always mean a romantic date?

Not at all! While English speakers often use it to mean a romantic meetup, in everyday French a rendez-vous is the standard word for any kind of appointment, like seeing a doctor, a hairdresser, or a business client.

Could I use Il instead of Ça to say "It depends"?

You should stick to Ça dépend. When saying "It depends" as a general statement, French speakers use ça (meaning "that" or "it" in a general sense) rather than il, which is usually reserved for replacing a specific masculine noun.