Learn Dutch: Wanneer is de winkel open?

Yes! If you want to know the exact time on the clock, you can ask Hoe laat is de winkel open? (What time is the shop open?). Wanneer (when) is a bit broader and could also refer to days of the week.

Why does the verb is come before de winkel?

In Dutch questions that start with a question word like wanneer (when), the verb always comes immediately after the question word. The subject (de winkel) comes right after the verb.

Is the word open used exactly like in English?

Yes, open is spelled the same and means exactly the same thing. The pronunciation is just a bit different: the o in Dutch is a long, pure sound, so it sounds a bit more like OH-pun.