The negative adjective (nessun, nessuna)

To express having zero options or "not any" of something, Italian uses the negative adjective nessuno. When placed before a noun, its ending changes to match the noun's gender and starting letters.

If you know how to use the indefinite articles (un, uno, una, un'), you already know how to use the forms of nessuno! Also, notice that Italian embraces the double negative: you will typically use non before the verb along with the negative adjective.

Masculine Nouns: Nessun and Nessuno

For most masculine nouns—whether they start with a regular consonant or a vowel—use nessun (following the exact same rule as un).

It makes no sense, there is nothing to understand.
Non ha nessun senso, non c'è niente da capire.
He made no mistake in the test.
Non ha fatto nessun errore nel test.

However, if a masculine noun starts with s + consonant (like spreco or scampo), z, gn, or ps, you must use nessuno (just like uno).

We do not want any waste of money.
Non vogliamo nessuno spreco di soldi.
Unfortunately there is no escape for them.
Purtroppo non c'è nessuno scampo per loro.

Feminine Nouns: Nessuna and Nessun'

For feminine nouns starting with a consonant, use nessuna (just like una).

There is no possibility of changing the situation.
Non c'è nessuna possibilità di cambiare la situazione.

Here is a sentence contrasting the feminine nessuna with the masculine nessuno:

Without the map, there is no hope nor any escape.
Senza la mappa, non c'è nessuna speranza né nessuno scampo.

Finally, if a feminine noun starts with a vowel, drop the final -a and add an apostrophe to make nessun' (just like un'). Remember, this apostrophe is only used with feminine nouns!

The lawyer made no objection.
L'avvocato non ha fatto nessun'obiezione.
He rejected the possibility without any hesitation.
Ha rifiutato la possibilità senza nessun'esitazione.

Contributors