Todavía me duele el tobillo por el esguince, así que descanso en casa.

My ankle still hurts because of the sprain, so I rest at home.

Breakdown of Todavía me duele el tobillo por el esguince, así que descanso en casa.

• yo: I
• descansar: to rest
• me: me
• así que: so

Questions & Answers about Todavía me duele el tobillo por el esguince, así que descanso en casa.

Why does Spanish say me duele el tobillo instead of something like yo duelo mi tobillo?

Because Spanish expresses pain with the verb doler using an indirect object structure:

• Me duele el tobillo literally works like The ankle hurts to me = My ankle hurts.
  So el tobillo is the subject of duele, and me indicates who experiences the pain.
  That’s why you don’t say yo duelo (that’s not how doler works).

Why is it duele (3rd person) and not duelo (1st person)?

Because the thing that hurts (el tobillo) is the grammatical subject.

• el tobillo (singular) → duele
  If you had multiple things hurting, you’d use plural:
• Me duelen los tobillos (My ankles hurt.)

What exactly does me mean here, and can it be replaced?

Me is the indirect object pronoun meaning to me / for me in this pain expression. It can change with the person:

• Te duele (your hurts / it hurts you)
• Le duele (his/her/your-formal hurts)
• Nos duele (ours hurts / it hurts us)

Why is it el tobillo (the ankle) and not mi tobillo (my ankle)?