unkouzyouhou ni ouzite, nitteihenkou wo suru.

It has a very common Japanese pattern:

A に応じて、B をする

• A = the basis or condition
• に応じて = in accordance with / depending on / in response to
• B をする = do B

So here:

• 運航情報 = flight/operation information
• に応じて = according to that information
• 日程変更をする = make a schedule change / change the itinerary

A natural structural gloss is:

According to the operation/flight information, make a schedule change.

Japanese often leaves out the subject, so the sentence focuses on the action and condition rather than on who does it.

に応じて comes from the verb 応じる, which means to respond to, to correspond to, or to act in accordance with.

In this sentence, に応じて means something like:

• depending on
• according to
• in response to
• based on

The nuance is not random uncertainty. It suggests that the action is adjusted in line with some information or circumstances.

So 運航情報に応じて means:

• adjust your action based on the flight/operation information
• respond appropriately to the current operation status

In A に応じて, the particle に is part of the fixed grammar pattern.

It does not mean location here.
It marks the thing that the response or adjustment is based on.

So:

• 運航情報に応じて = in accordance with the flight/operation information

You can think of に here as connecting the standard/basis to the response.

Other similar examples:

• 人数に応じて席を用意する。
  Prepare seats according to the number of people.

• 状況に応じて対応する。
  Respond according to the situation.

This is a very common Japanese pattern:

noun + をする

Here, 日程変更 is a verbal noun-like expression meaning schedule change or itinerary change, and をする turns it into an action: to make a schedule change.

That said, many learners will notice that 日程を変更する is also very common and often sounds more straightforward.

Compare:

• 日程変更をする = do a schedule change
• 日程を変更する = change the schedule

Both can be natural, but 日程を変更する is often the more direct wording in ordinary prose.
日程変更をする can sound a bit more administrative, procedural, or announcement-like.

Yes, it is understandable and natural enough, especially in formal, written, or administrative contexts.

However, many native speakers might more often say:

• 日程を変更する
• 日程を変更します
• 運航情報に応じて、日程を変更する

So if you are learning what sounds most standard in general use, 日程を変更する is probably the version to remember first.

Still, 日程変更 is a very common noun in travel, event planning, and business contexts, so 日程変更をする is not strange.

That is normal in Japanese. The subject is omitted because it is understood from context.

Depending on the situation, the hidden subject could be:

• we
• you
• the company
• the traveler
• staff

For example, in a notice it might mean:

• We will change the schedule according to flight information.
• Please change your schedule according to flight information.

Japanese very often leaves out subjects when they are obvious from context.

By itself, it can sound slightly like a written instruction, guideline, or policy statement rather than a fully fleshed-out conversational sentence.

Why?

• It uses plain dictionary-style wording: する
• It omits the subject
• It is compact and formal
• It has a business/announcement feel

So in real life, this might appear in:

• a policy manual
• a travel notice
• an operations guideline
• a checklist item

In conversation, someone might say a fuller version such as:

• 運航情報に応じて、日程を変更します。
• 運航情報に応じて、日程を変更してください。

The readings are:

• 運航情報 → うんこうじょうほう
• 応じて → おうじて
• 日程変更 → にっていへんこう
• する → する

A few notes:

• 運航 is often used for the operation of flights, ships, and other transport services.
• 変更 is a very common word meaning change or modification.

運航情報 usually means operational information about transportation service, especially things like:

• delays
• cancellations
• route changes
• service status
• departure/arrival updates

In an airline context, it often means current flight operation information.
Depending on context, it could also apply to trains, buses, ferries, or other transport systems, though 運航 is especially common with aircraft and vessels.

So the sentence suggests that the schedule should be changed based on current transport operation updates.

The comma simply separates the condition from the main action, making the sentence easier to read.

• 運航情報に応じて、日程変更をする。

Without the comma, the meaning would stay basically the same:

• 運航情報に応じて日程変更をする。

In formal writing, Japanese often uses commas to clearly mark where one chunk ends and the main statement begins.

It is plain form, but not casual in tone. It feels neutral, formal, and written.

Why?

• The verb ends in する, not します
• The vocabulary is formal/administrative
• The sentence is concise and impersonal

So it is grammatically plain, but stylistically it can sound more official than casual speech.

Compare:

• 日程変更をする。 → plain, written, neutral
• 日程変更をします。 → polite
• 日程変更をしてください。 → polite request
• 日程を変える。 → more everyday and conversational

Sometimes, yes, but the nuance changes slightly.

Possible alternatives include:

• 運航情報によって
  depending on the operation information

• 運航情報を見て
  after looking at the operation information

• 運航状況に合わせて
  in line with the operating situation

But に応じて is especially good when you want the meaning of:

• adjust appropriately
• respond to conditions
• act in accordance with information

So in a formal sentence like this, に応じて is a very natural choice.